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Investment in Calcivis tooth decay technology helps fund expansion

Mark Sterritt (British Business Bank), Adam Christie (Calcivis), Paul Callaghan (Scottish National Investment Bank) and David Milroy (Maven Capital Partners).


Edinburgh BioQuarter-based biotechnology company,  CALCIVIS®  has secured £5 million in funding to help roll out its cutting-edge dental technology.

This latest investment round was led by £4 million in funding from the Scottish National Investment Bank along with £1 million from IFS Maven Equity Finance, which is managed by Maven Capital Partners and is part of the Investment Fund for Scotland (IFS), delivered by the British Business Bank.

Since it was founded in 2012, CALCIVIS has raised more than £18 million in funding with investors including Scottish Enterprise and Archangels.

The patented system of CALCIVIS® enables early detection of tooth decay – which in turn can enable timely preventive treatment – by deploying a biologic diagnostic agent in combination with an imaging device.

The firm aims to revolutionise early-intervention diagnostics in dentistry. Its technology uses “bioluminescence” to highlight quickly and clearly where preventive measures are required before decay becomes irreversible.

CALCIVIS will use the funds to bring its flagship product to market in the US after the Food and Drug Administration (FDA) granted premarket approval. The system is the first Scottish medical device to secure this certification from the FDA.

The US market is the largest for medical technology and Calcivis anticipates a subsequent launch in the UK and other European markets.

Calcivis CEO Adam Christie said: “ Early diagnosis and treatment of tooth decay is essential, allowing patients to reverse the damage to their teeth before it is too late.

“This investment will enable us to launch our innovative product to global markets – first in the US and eventually in the UK – leading to faster diagnoses and early intervention treatments.

“This technology has the potential to revolutionise prevention in oral health care, with cavities impacting more than two billion people globally, according to the World Health Organisation.

“We look forward to seeing where this product can go with the support of both the Scottish National Investment Bank, and the Investment Fund for Scotland, through Maven.”

Scottish National Investment investment director Paul Callaghan said: “ Calcivis is a shining example of how Scotland is leading the way in developing cutting-edge technology that improves our health and wellbeing.

“We are proud to help the company scale-up and enable its flagship product to reach international markets, creating jobs in Scotland.

“As a development investment bank, we see Calcivis’ technology as fully aligned with our Innovation mission, and the product’s launch in the UK has the potential to deliver substantial health benefits to people in Scotland.”

Maven Partner David Milroy said: “ Tooth decay is the most common nontransmissible disease globally and is believed to cost western economies over $300 billion annually, much of which is spent treating, rather than preventing damage to our teeth.

“Maven is therefore delighted to be supporting Calcivis’ revolutionary technology. We look forward to working with the Calcivis team as they launch this exciting new product.”

Ken Cooper, Managing Director, Venture Solutions, at the British Business Bank, said: “ Health tech and life sciences are key areas of opportunity for the Scottish economy and, through the Investment Fund for Scotland, we’re committed to supporting businesses with high-growth potential, such as Calcivis.”

Sarah Hardy, Head of New Investments and Director at Archangels, said: “ We are delighted to welcome the Bank and the Investment Fund for Scotland through Maven, alongside our strong syndicate of investors at this exciting juncture as we roll out a new level of preventive dentistry with the revolutionary Calcivis product.”

CALCIVIS is based at Edinburgh BioQuarter, where it continues to expand its research and development operations and explore innovative, lower carbon manufacturing processes. Co-founded in 2012 by Adam Christie (CEO) and Bruce Vernon (CTO), the CALCIVIS® team combines product development, clinical and commercial expertise.

The CALCIVIS® Imaging System was developed with input from leading International specialists in caries and erosion. Since then multiple preclinical and clinical studies have been undertaken including one pivotal clinical study designed to support our regulatory filing to the FDA leading to it’s approval.

Additionally, the CALCIVIS® Imaging System has the UKCA mark for the UK.

CALCIVIS® is internationally focused and actively forming relationships with leading clinicians and other stakeholders in dental markets around the world.

Calcivis targets US Expansion after securing FDA PMA Approval